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Cochrane Library: PICO Search

High-quality, independent evidence to inform healthcare decision-making

Using PICO to Formulate an Answerable Question

PICO is a mnemonic that helps you formulate a specific, answerable clinical or research question.

P = Patient (population or problem) - Who or what are you studying?
I = Intervention  - What is the diagnostic test, treatment or therapy? Or what are the prognostic factors or exposures?
C = Comparison - What are you measuring this intervention against?
O = Outcome(s) - What are you trying to accomplish, measure, improve or effect?

Learn more about the role of PICO in evidence-based practice

Cochrane PICO Search

Phone: 515-271-1537